概述
目标是停止免疫机制的不平衡, reverse and ultimately cure immune-mediated diseases such as 系统性红斑狼疮, 炎症性肠病, 类风湿关节炎和特应性皮炎是澳门葡京网赌游戏澳门葡京赌博游戏R快速扩张的全球免疫团队的雄心勃勃的目标&D.
Building on decades of experience in unravelling complex inflammatory cell signalling pathways, 澳门葡京赌博游戏的科学家专注于将保护性免疫反应转化为关节破坏性力量的关键机制, 消化系统, 皮肤和其他重要器官.
帮助推动快速发展, we are recruiting highly skilled scientists who are eager to innovate and shape the future of 免疫学 at AstraZeneca. 澳门葡京赌博游戏的研究团队致力于提供精准药物，旨在改变免疫介导疾病患者的生活.
介绍
With an estimated 5 million people living with a form of Lupus worldwide,1 6.800万人患有炎症性肠病2 2000万人患有类风湿关节炎3 and 15-20% of children and 1-3% of adults with Atopic Dermatitis,4 there is a well-established need for innovative therapies that target key immune mechanisms underlying these diseases.
Acute inflammation in response to injury or infection has a natural ‘off’ switch to allow healing. 但是在自身免疫性疾病中, some triggers may persist and faulty ‘off’ switches mean that continued inflammation leads to tissue damage, 破坏和疤痕. 免疫介导性疾病的慢性本质也意味着下一代治疗方法需要超越症状控制.
Key areas of focus for immunology research at AstraZeneca
- 嗜酸性粒细胞水平升高, 澳门葡京赌博游戏已经瞄准了哮喘的免疫细胞, now investigated in disorders affecting multiple body systems, 包括胃肠道疾病和皮肤病.
- 1型干扰素, 免疫系统中的关键细胞信号分子, now investigated in 红斑狼疮 and a broad range of diseases including Lupus Nephritis, 皮肤红斑狼疮和肌炎.
- The complement system of immune cell enhancing proteins, 以前主要针对罕见疾病, now investigated in more common autoimmune disorders.
共享生物，共享解决方案
澳门葡京赌博游戏正在深入研究疾病生物学，以开发新的和潜在的变革性解决方案，解决现有疗法尚未开发的广泛病理问题. We aim to hit hard at multiple pathways to achieve lasting benefits for patients with immune-mediated diseases.
By gaining a better understanding of the biology of autoimmune diseases, our aim is to target the causes rather than the consequences of the inflammatory processes that are at work.
Precision 免疫学: right pathway, right patient, right time
As immunemediated diseases affect highly heterogeneous populations, it is essential to develop precision medicines with biomarkers that can readily identify patients most likely to benefit.
在系统性红斑狼疮, clinical trials of a potential antibody treatment that inhibits the activity of type 1 interferons are well advanced. Our researchers have successfully targeted the type 1 interferon signalling pathway, which is known to play a key role in 系统性红斑狼疮 disease activity as well as other immune-mediated diseases.5
炎症性肠病, 细胞因子的表达, interleukin-23 (IL-23), has been linked with inflammatory changes in the gut, and antibody therapies are in development to inhibit the IL-23 pathway.6 Our research is investigating the use of molecular endpoints along the IL-23 pathway, as biomarkers to identify patients most likely to benefit from anti-IL-23 therapy.
新颖的治疗: 调节性T细胞疗法
在澳门葡京网赌游戏, 澳门葡京赌博游戏正在研究自身免疫性疾病和炎症性疾病患者免疫系统中调节性T细胞(Treg)功能的丧失，这可能导致有害的炎症过程，损害健康组织. Re-balancing systems that have failed to maintain immune homeostasis have great potential for innovative, 炎症性肠病的长期治疗, 系统性红斑狼疮 and Rheumatoid Arthritis. Our research is focused on the development of Treg cells which remain stable and retain their original function, 没有恶化, 当重新注入病人体内时.
未来的发展方向
澳门葡京赌博游戏免疫学研究的广度和深度, 整合最新数字技术的能力, AI, CRISPR和其他技术应用到澳门葡京赌博游戏的项目中, and the collaborations with world-leading experts at some of the finest research centres worldwide, make AstraZeneca a highly stimulating and exciting place to work. Already widely used for drug discovery at AstraZeneca R&D, 澳门葡京赌博游戏先进的CRISPR技术有望在治疗中发挥越来越大的作用，其目的是纠正自身免疫性疾病中导致异常信号通路的基因突变，从而为一些患者带来治愈的诱人可能性, 直到有一天, 希望生活得更好, 更健康的生活.
